Summary of “Drugs To Fight ‘Neglected Tropical Diseases’ Can Cost Far More In The U.S. Than Abroad”

It’s one of several drugs for “Neglected tropical diseases” that are priced differently in the United States than they are in the developing world.
Drugs for diseases of the developing world, in particular what are known as “Neglected tropical diseases” like hookworm and leishmaniasis, are enormously more expensive in the United States than in the developing world.
Prices for generic drugs that treat neglected tropical diseases are skyrocketing in the U.S. When a disease affects only a small number of patients in the U.S., “There’s less incentive for generic companies to enter the market,” Alpern explains.
Dr. Peter Hotez, dean of the National School of Tropical Medicine at the Baylor College of Medicine, says certain neglected tropical diseases in the U.S. are surprisingly widespread, especially among those who may not be able to afford treatment.
“We have now identified nearly half-a-dozen neglected tropical diseases that are widespread in the U.S. among the poor, especially in the American South,” says Hotez, who last year published Blue Marble Health, a book evaluating neglected diseases in America.
In the years following albendazole’s price hike in 2011, Medicaid spending on the drug went from under $100,000 in 2008 to more than $7.5 million in 2013.
Medicaid spending on Daraprim, another tropical disease drug that just experienced a price hike, went from $2.2 million in 2014 to $15.7 million in 2015.
According to its website, Impax is “Committed to making ENVERM more affordable.” The pharmaceutical company shared an online coupon that can save patients up to $60 for a prescription that would cost more than $369. Alpern hopes to see more companies start manufacturing the generic version of the drug.

The orginal article.

Summary of “Modern life is lonely. We all need someone to help”

What these stories illustrate is the way in which the threat of loneliness is hardwired into modern life.
Practical people doing practical things – travelling far for a job opportunity, opting for the accommodation they can afford, under unbending rules – learn the hard way that human beings can only take so much practical.
Engineering a large-scale change in people’s feelings – it’s a hard thing to do.
Most people understand that loneliness is neither necessarily felt by people who are alone, nor alien to people who are always with others.
Even a community with little in the way of material resources finds some contentment in being in a group of people who are all in it together.
The Cox report mentions social institutions that are becoming a less and less common aspect of people’s daily lives – church, local pub, workplace, social club.
Even schools feel like high-pressure environments rather than places where people are nurtured and coaxed through childhood.
How anyone at all still manages to feel secure in their own company is the real mystery of life today.

The orginal article.

Summary of “What You Need to Know Before Seeing Star Wars: The Last Jedi”

The New Republic didn’t want to jeopardize the peace by attacking them, but it looked the other way when erstwhile princess Leia Organa formed a paramilitary force called the Resistance to fight the First Order.
Back in the original trilogy of Star Wars flicks, Luke went from podunk farm boy to last living practitioner of the ancient Jedi arts.
Luke felt responsible for what happened and went into self-imposed exile, searching for the first temple of the Jedi.
The First Order and the Resistance both showed up and launched into a battle, during which Kylo nabbed her.
Once he’d destroyed the Jedi academy, Kylo joined up with Snoke’s First Order and sought to be as powerful a practitioner of the dark arts as his idolized grandfather, Darth Vader.
At Maz Kanata’s castle, he gave up his little fib and tried to abandon the mission out of fear, but was reinvigorated after seeing the First Order blow up the New Republican capital.
Leia OrganaThe Galaxy’s premiere badass member of a royal family had a rough go of it in TFA. As we mentioned earlier, she was the leader of the Resistance, having formed it in response to the New Republic’s inaction to the rise of the First Order.
When we last saw him, he told Hux to get Kylo and escape Starkiller Base so Snoke could complete Kylo’s training.

The orginal article.

Summary of “Stopping the Rise of Superbugs by Making Them Fight For Food”

Every time scientists identify a new substance that can hold back the tide of infectious disease, resistant superbugs surge over that barrier in a matter of years.
So why aren’t all microbes already resistant to all drugs?
These costs mean that, under normal conditions, resistant microbes grow more slowly than their susceptible peers, and are almost always outcompeted.
Antibiotics tip the balance of this competition by finally giving the resistant microbes a huge advantage; their susceptible rivals die off, and they can finally take over.
These alternatives are shut down by the same mutations that make the parasites resistant to pyrimethamine.
That’s encouraging, Wale says, especially because she used tens of thousands of resistant parasites in these competitive experiments-far more than would normally exist when they first emerge in the real world.
These “Resource limiters” aren’t meant to kill the parasites, but to put the resistant ones at a perpetual disadvantage so a standard antibiotic can finish off the rest.
Some groups are working on substances that stop antibiotics from reaching the gut, and fomenting the evolution of resistant superbugs there.

The orginal article.

Summary of “Switzerland is Prepared for Civilizational Collapse”

More than any other country, Switzerland’s ethos is centered around preparing for civilizational collapse.
Zurich is famous for its 1200 fountains, some of them quite beautiful and ornate, but it’s the multiple small, simple fountains in every Swiss village that really tell the story.
If the central government fails, the Swiss might not even notice.
Swiss males are required to serve in the military creating a robust reservoir of trained citizens ready to serve in an emergency.
As a further example of how ridiculously well prepared the Swiss are for any and all threats, there are things like hidden hydroelectric dams built inside of unmarked mountains so that in the event of mass bombings, they’ll still have electricity from these secret facilities.
To thousands of military bunkers permeating the Swiss mountains there are several hundred thousand private and public fallout shelters the largest of which can hold some 20,000 people.
As the Swiss continue to improve their already fantastic railway system it’s standard practice to convert old railway tunnels to security shelters.
It’s no surprise that Nassim Taleb likes Switzerland because this is a country that has made itself anti-fragile in order to survive the black swans of civilizational collapse.

The orginal article.

Summary of “Everybody Should Fear the Disney Death Star”

Disney announced on Thursday that it would acquire most of the entertainment assets of 21st Century Fox for about $60 billion in stock and debt, in what would be the largest-ever merger of two showbiz companies.
Already the most storied entertainment empire in the U.S., Disney would become a global colossus through this deal, gaining large stakes in the biggest entertainment companies in both Europe and India.
In the transfer of power, Disney would receive the 20th Century Fox film studio, including the independent film maestros at Fox Searchlight, the X-Men franchise, Fox’s television production company, the FX and National Geographic cable channels, and regional sports networks, including the YES Network that broadcasts New York Yankees games.
These additions would enrich an overflowing treasury at Disney, whose assets includes Star Wars, Marvel, Pixar, ABC, ESPN, the world’s most popular amusement parks, and, of course, its classic animated-film division.
Disney is paying $60 billion to build a business that reaches everybody else-every youthful, colorful, nose-diving line segment in the chart.
If the Justice Department permits the Disney merger without a peep, it will feed speculation about why the government is blocking the acquisition of the president’s most-hated television channel.
Consumers should fear too; not just those who are afraid that Disney will water down artsy filmmaking and R-rated superhero films, but also those who are afraid that too much control of any industry confers monopoly power that restricts choices, raises prices, and hurts workers.
Here’s the truly weird part: Disney should also be afraid of its own Death Star.

The orginal article.

Summary of “The Force Belongs To Us: THE LAST JEDI’s Beautiful Refocusing of Star Wars – FILM CRIT HULK! HULK BLOG!”

A charming way of storytelling that whispers sweet nothings in your ear and is out the window before you wake up.
In making a Episode 7, I was hoping he’d cast it aside, and in some ways he did, and in some ways doubled down on some of his worst story habits of “Momentary effect” over building to a coherent point.
Sometimes it’s done in a funny way, sometimes in an incredulous way, but it’s always in purposeful way.
So for something to be “Invisible” and for you to be “In it” is not necessarily a virtue of any filmmakers ability or the lack, but largely what we bring in our own way of seeing.
The way the film plays with audience expectations with her is never a “Ta-da! surprised you, didn’t I!?” It’s what most good turns do in that they make you slap your forehead and go “Of course!” Poe’s mutiny was always misguided, him repeating the mistakes of the past.
Because it has to earn so much of the real biggest mystery presented in the last film and that’s WHY, why would Luke ever do this and run away? The answer, and then the films answer to that answer, is one of the most brilliant last lessons that the Star Wars universe has yet to give: and that is the acceptance of / and learning from failure.
“My friend said this in a conversation a long time ago. And he didn’t mean it about the characters themselves, nor what they meant to him. He meant it in the sense of the Star Wars series’ focus on lineage and the way some all powerful family who are the most powerful force users who basically controlled the fate of galaxy was super gross. And he’s right, quite frankly. Because it’s everything I hate about the notion of ‘destiny” and “Why I’m destined to be a hero!” bullshit.
Who, within them so innately carry the understanding of the horrors of that world, and thus so tangibly know the simple, inescapable ways for it to be better.

The orginal article.

Summary of “How SpongeBob SquarePants came to life on Broadway”

SpongeBob SquarePants, of the 18-year-old Nickelodeon cartoon, is a talking yellow kitchen sponge with a head that takes up more than two-thirds of his body.
This is all just to say, for designer David Zinn, when it came to bringing SpongeBob SquarePants to the stage, the question of the pineapple under the sea turned out to be the least of his problems.
SpongeBob SquarePants debuted on Broadway on December 4, at the Palace Theatre.
“You’re doing SpongeBob SquarePants, so at some point, you kind of have to use a kitchen sponge,” he said; for one backdrop, in an opening scene, he wound up using more than 4,000.
SpongeBob came with its own bizarre constraints.
In the end, it was less a matter of dressing up like SpongeBob than finding a way to transmit SpongeBob’s essence.
The earliest SpongeBob SquarePants workshops included actors, designers, a Foley artist, a choreographer, and a clowning expert.
If cartoons succeed by surprising a viewer with all in the world that is not possible, then this real-life version of SpongeBob SquarePants similarly surprises with all the things that are.

The orginal article.

Summary of “A Simple Checklist To Help You Not Get Hacked”

While many people are pretty vigilant about their personal security, be it financial, physical, mental, or otherwise, most of us internet users are far less motivated, and much less educated, when it comes to the security of our data.
Bruce Schneier, a noted cryptographer and digital security specialist who serves on the project’s advisory board, points to a handful of good existing resources on internet security, including EFF’s Surveillance Self-Defense, Front Line Defenders’ Digital Protection, and Motherboard’s recently published guide to not getting hacked.
Security Planner isn’t meant to replace these guides, Schneier says: instead, it’s for users who want to improve their online security immediately without getting too deep into the intricacies of an ever-evolving set of technologies.
To gather recommendations, Citizen Lab is managing a peer review group of security professionals, including Dr. Angela Sasse of University College London and Jamie Tomasello of Duo Security, as well as activist organizations like the Guardian Project and the Tibet Action Institute.
Apart from personalized tips, Security Planner also allows users to see all recommendations for browsing, computers, online accounts, smartphones, and internet connections, among other areas of interest.
For more secure browsing Security Planner recommends installing HTTPS Everywhere, which encrypts a user’s connection to thousands of websites for secure surfing.
For securing phone data, Security Planner recommends Whisper Systems’ Signal, which allows users to call and text privately via encryption.
“Most commercial spyware, built by the cyberweapons manufacturers, as I call them, relies on basic vulnerabilities and simple tricks, so Security Planner will do better than the average user against this type of attacker,” he says.

The orginal article.

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Good credit can get you better mortgage interest/auto loan rates, which can save you thousands over a lifetime.
Your credit can impact everything from your bills to your car loan to your ability to land the.
It’s based on your credit utilization, or how much of your credit limit you use.
Experts recommend using up no more than 30% of your limit-regardless of whether or not you pay it all off each month-in a given credit cycle to maximize your score.
If you have more than one card, you should aim for 30% of the cumulative credit available.
It’s good to have a mix, but don’t apply for a mortgage to boost your credit.
Beyond understanding your score, you should check your credit report for errors, and dispute them by contacting the bureaus.
Freeze your credit unless you’re going to buy a home, car, etc.

The orginal article.