Summary of “Fresh Air: ‘Never Enough’ Explains The Biology Of The Addicted Brain”

The changes in behavior that happen during adolescence are so important and lasting, because the brain is forming permanent structures.
So whatever you experience as an adolescent is going to have a much more impactful influence on the rest of your life trajectory than it would, say, if you did this at another time in development when your brain wasn’t so prone to changing.
We see definitely lasting changes on the brain and behavior.
It’s a tiny, tiny molecule, and it acts all over the brain in so many different pathways.
So it’s like cocaine in that its actions are very specific, and it’s like alcohol in that those actions are all over the brain.
When we smoke marijuana the whole brain is flooded with THC, and that causes the cell-to-cell communication in cells throughout the brain to be enhanced or to be exaggerated.
What’s unfortunate is the brain does adapt to that, and it adapts by decreasing the number of sites that THC can have an effect [on].
The problem is if we reduce suffering and we produce euphoria using opiates, the brain adapts.

The orginal article.